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Clomiphene citrate is used to induce ovulation in women. However, clomiphene given to men fails to produce consistently increases in sperm count. This drug is a mixture of two geometric isomers with different properties. Enclomiphene citrate (the trans- or (E)-isomer) has effects consistent with estrogen antagonism whereas zuclomiphene citrate (the cis- or (Z)-isomer) often acts as an agonist ...

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